Family · Pharmaceutical analytical standards
Avacopan
An oral antagonist of the receptor for complement fragment C5a, approved in 2021 in Japan and the United States for ANCA-associated vasculitis (granulomatosis with polyangiitis and microscopic polyangiitis); in the European Union, where it was authorised in 2022, the authorisation was revoked in 2026. This family brings together the active ingredient, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?It was the first oral inhibitor of the complement C5a receptor approved in the United States, and both the FDA and the EMA considered it a first-in-class medicine.
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