Active ingredientBinimetinibCat. No. P-B083-001CAS 606143-89-9Family · Pharmaceutical analytical standards
Binimetinib
An oral inhibitor of the MEK1 and MEK2 kinases, approved in 2018 together with the BRAF inhibitor encorafenib for advanced melanoma with a BRAF V600 mutation, and later also for some lung cancers carrying the same mutation. This family brings together the active ingredient, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?The ending '-metinib' marks MEK inhibitors: like trametinib and cobimetinib it is paired with a BRAF inhibitor, to block two successive steps of the same signalling pathway that drives tumour growth.
Go to the active ingredient →Active ingredientBinimetinibCat. No. P-B083-001CAS 606143-89-9
MetaboliteBinimetinib GlucuronideCat. No. P-B083-003
Isotopically labelledBinimetinib-13C-d3Cat. No. P-B083-004
NitrosamineN-Nitroso BinimetinibCat. No. P-B083-005
Impurity1,2-Bis(aminooxy) Ethane DihydrochlorideCat. No. P-B083-006CAS 104845-83-2
Impurity2,3,4-Trifluoro-6-nitrobenzoic acidCat. No. P-B083-007CAS 132920-93-5
Impurity2,4-Diamino-3-fluoro-5-nitrobenzoic acidCat. No. P-B083-008CAS 918321-31-0
Impurity2-(Ethenyloxy)-2-methylpropaneCat. No. P-B083-009CAS 926-02-3
Impurity4-Amino-2,3-difluoro-5-nitrobenzoic acidCat. No. P-B083-010CAS 284030-57-5
ImpurityBinimetinib Acetyl ImpurityCat. No. P-B083-011
ImpurityBinimetinib Acid ImpurityCat. No. P-B083-012CAS 1415564-99-6
ImpurityBinimetinib Amide ImpurityCat. No. P-B083-013
ImpurityBinimetinib Des Bromo Acid ImpurityCat. No. P-B083-014CAS 2649854-87-3
ImpurityBinimetinib Des Bromo ImpurityCat. No. P-B083-015
ImpurityBinimetinib Des Bromo Vinyloxy ImpurityCat. No. P-B083-016CAS 2649854-88-4
ImpurityBinimetinib Ethyl Ether ImpurityCat. No. P-B083-017
ImpurityBinimetinib Impurity 1Cat. No. P-B083-025CAS 2509103-99-3
ImpurityBinimetinib Internal Cyclized ImpurityCat. No. P-B083-028
ImpurityBinimetinib Methyl EsterCat. No. P-B083-029CAS 1415559-93-1
ImpurityN-Desmethyl BinimetinibCat. No. P-B083-030
ImpurityN-Desmethyl Binimetinib HClCat. No. P-B083-031No product matches your search.
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