Family · Pharmaceutical analytical standards
Colistimethate
A prodrug of colistin (polymyxin E) in which sulphomethyl groups make the molecule less toxic when injected; available since 1959, it is given intravenously or by inhalation against multidrug-resistant Gram-negative bacteria, often as a last resort. This family brings together the active ingredient.
Did you know?Colistin was isolated in Japan in the late 1940s from a culture of Bacillus polymyxa var. colistinus; largely abandoned in the 1980s, it came back into use in the 1990s against multidrug-resistant bacteria.
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EDQM standards 4
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
