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Family · Pharmaceutical analytical standards

Colistimethate

A prodrug of colistin (polymyxin E) in which sulphomethyl groups make the molecule less toxic when injected; available since 1959, it is given intravenously or by inhalation against multidrug-resistant Gram-negative bacteria, often as a last resort. This family brings together the active ingredient.

Did you know?Colistin was isolated in Japan in the late 1940s from a culture of Bacillus polymyxa var. colistinus; largely abandoned in the 1980s, it came back into use in the 1990s against multidrug-resistant bacteria.

Colistimethate SodiumGo to the active ingredient →

EDQM standards 4

The official European Pharmacopoeia standards for this family.

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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.