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Family · Pharmaceutical analytical standards

Dacarbazine

An alkylating chemotherapy drug synthesised in 1959 in Alabama and approved in the United States in 1975: it is used for metastatic melanoma and, in the ABVD regimen, for Hodgkin lymphoma. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards and other impurities.

Did you know?It is a prodrug: it becomes active only in the liver, where it turns into MTIC, the molecule that attaches methyl groups to the DNA of tumour cells. It is on the WHO List of Essential Medicines.

DacarbazineGo to the active ingredient →
DacarbazineActive ingredientDacarbazineCat. No. P-D003-001CAS 4342-03-4
Dacarbazine-d6Isotopically labelledDacarbazine-d6Cat. No. P-D003-008CAS 1185241-28-4

EDQM standards 3

The official European Pharmacopoeia standards for this family.

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