Family · Pharmaceutical analytical standards
Dacarbazine
An alkylating chemotherapy drug synthesised in 1959 in Alabama and approved in the United States in 1975: it is used for metastatic melanoma and, in the ABVD regimen, for Hodgkin lymphoma. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards and other impurities.
Did you know?It is a prodrug: it becomes active only in the liver, where it turns into MTIC, the molecule that attaches methyl groups to the DNA of tumour cells. It is on the WHO List of Essential Medicines.
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EDQM standards 3
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
