Family · Pharmaceutical analytical standards
Debrisoquin
A guanidine-derived antihypertensive, similar to guanethidine, patented in 1963 and used for high blood pressure; today it serves mainly as a 'probe' drug for measuring the activity of the liver enzyme CYP2D6. This family brings together the active ingredient.
Did you know?In 1975 in London pharmacologist Robert Smith took it along with four other volunteers: only he had a sharp fall in blood pressure, because he could not break it down. It was a genetic variant found in 5-10% of people of European descent.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
