Active ingredientDeruxtecanCat. No. P-D051-001CAS 1599440-13-7Family · Pharmaceutical analytical standards
Deruxtecan
A derivative of exatecan, itself an analogue of camptothecin, that blocks topoisomerase I and damages the DNA of cancer cells: it is the cytotoxic 'payload' attached to antibodies in several antibody-drug conjugates, the first of which was approved in the United States in 2019. This family brings together the active ingredient.
Did you know?It descends from camptothecin, discovered in 1966 by Monroe Wall and Mansukh Wani in the bark of Camptotheca acuminata, a Chinese tree whose name is often translated as 'happy tree'.
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