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Family · Pharmaceutical analytical standards

Fluorouracil

An antimetabolite anticancer drug, an analogue of uracil carrying a fluorine atom, which blocks DNA synthesis in rapidly dividing cells. Reported in 1957 by Charles Heidelberger, it has been used since the 1960s for tumours such as colon and breast cancer and, as a cream, for some skin lesions. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards and other impurities.

Did you know?It was designed on purpose: in 1954 researchers had seen that liver tumours take up uracil more avidly than healthy tissue, so Heidelberger imagined a uracil "in disguise" carrying a fluorine atom.

FluorouracilGo to the active ingredient →
FluorouracilActive ingredientFluorouracilCat. No. P-F091-001CAS 51-21-8
UracilPharmacopoeial impurityUracilCat. No. P-F091-003CAS 66-22-8

EDQM standards 5

The official European Pharmacopoeia standards for this family.

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