Family · Pharmaceutical analytical standards
Ibrutinib
An oral inhibitor of Bruton's tyrosine kinase (BTK), an enzyme essential for the survival of B lymphocytes. Approved in the United States in 2013, it is used in chronic lymphocytic leukaemia, mantle cell lymphoma and Waldenström's macroglobulinaemia. This family brings together the active ingredient, labelled standards, nitrosamines and other impurities.
Did you know?It was born as a simple laboratory 'tool' for studying BTK: its acrylamide group forms a covalent bond with cysteine 481 of the enzyme, switching it off for a long time.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
