Family · Pharmaceutical analytical standards
Irinotecan
A semisynthetic camptothecin derivative that blocks the enzyme topoisomerase I, stopping tumour cells from copying their DNA: synthesised in Japan in 1983 and approved in 1994, it is used mainly in colorectal cancer. This family brings together the active ingredient, pharmacopoeial impurities, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?The camptothecin it comes from was isolated in 1966 by Monroe Wall and Mansukh Wani from Camptotheca acuminata, known in China as the 'happy tree'. The same two chemists also discovered paclitaxel.
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EDQM standards 4
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
