Active ingredientKirromycinCat. No. P-K012-001CAS 50935-71-2Family · Pharmaceutical analytical standards
Kirromycin
An antibiotic made by the soil bacterium Streptomyces collinus, isolated by Wolf in Zähner's group in Tübingen and described in 1972: it blocks protein synthesis in bacteria by acting on the elongation factor EF-Tu. This family brings together the active ingredient.
Did you know?Its mechanism is unusual: it lets EF-Tu use up its GTP molecule, but then stops it from leaving the ribosome, which stays jammed; the producing strain, Tü 365, came from Kouroussa in Guinea.
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