Family · Pharmaceutical analytical standards
Lopinavir
An HIV protease inhibitor approved in 2000, available only in a fixed combination with a low dose of ritonavir: this blocks the CYP3A4 enzyme, which would otherwise clear lopinavir quickly, and greatly raises its blood levels. This family brings together the active ingredient, pharmacopoeial impurities, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?It was designed to improve on ritonavir by using X-rays to study how molecules fit into the virus's protease, with help from the Advanced Photon Source synchrotron at Argonne National Laboratory in the United States.
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EDQM standards 3
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
