Family · Pharmaceutical analytical standards
Metolazone
A thiazide-like diuretic with a quinazoline structure, patented in 1966 and approved in 1974 for heart failure, high blood pressure and oedema; it is often added to loop diuretics. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards, nitrosamines and other impurities.
Did you know?It is not a true thiazide, because it lacks the benzothiadiazine ring. It was developed by chemist Bola Vithal Shetty, who later helped the FDA review drug applications.
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