Family · Pharmaceutical analytical standards
Milbemycin
A family of antiparasitic macrolides related to the avermectins, first isolated in 1972 from the bacterium Streptomyces hygroscopicus: they open glutamate-sensitive chloride channels in invertebrates and are used in veterinary medicine against worms, ticks and fleas. This family brings together pharmacopoeial impurities and other impurities.
Did you know?Industrial fermentation yields far less of them than of the avermectins: in 2017 researchers swapped part of the genes and persuaded the avermectin bacterium, Streptomyces avermitilis, to make milbemycin instead.
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