Family · Pharmaceutical analytical standards
Monic Acid A
A 17-carbon polyketide that forms the core of mupirocin (pseudomonic acid A), an antibiotic isolated in 1971 from the bacterium Pseudomonas fluorescens: in mupirocin it is joined as an ester to 9-hydroxynonanoic acid. This family brings together the active ingredient and labelled standards.
Did you know?In mupirocin it is monic acid itself, the molecule's 'head', that resembles isoleucyl-adenylate: this way the antibiotic fools the bacterial enzyme that loads isoleucine onto tRNA and halts the bacteria's protein production.
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