Family · Pharmaceutical analytical standards
Nalidixic Acid
The forerunner of the quinolone antibacterials: it blocks bacterial DNA replication. It was described in 1962 by George Lesher and colleagues and entered clinical use in 1967 against urinary tract infections. This family brings together the active ingredient and other impurities.
Did you know?It was born almost by chance, from a byproduct of the synthesis of the antimalarial chloroquine. Strictly speaking it is not even a quinolone: its ring holds two nitrogen atoms, making it a naphthyridine derivative.
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