Family · Pharmaceutical analytical standards
Plazomicin
A next-generation aminoglycoside derived from sisomicin, approved in the United States in 2018 for complicated urinary tract infections, including pyelonephritis, when few alternatives remain: it curbs bacterial protein production. This family brings together the active ingredient and nitrosamines.
Did you know?A small hydroxyethyl group added to the molecule makes it immune to acetylation by AAC(6')-Ib, the most widespread of the acetylating enzymes bacteria use to inactivate aminoglycosides.
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