Family · Pharmaceutical analytical standards

Raloxifene

A selective oestrogen receptor modulator (SERM) approved in 1997 in the United States to prevent postmenopausal osteoporosis; since 2007 also to reduce the risk of invasive breast cancer. This family brings together the active ingredient, pharmacopoeial impurities, metabolites, labelled standards and other impurities.

Did you know?In the 1980s, when it was still called keoxifene, pharmacologist V. Craig Jordan saw in rats that it protected bone: some journals rejected his work, convinced that only oestrogens could do that.

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Active ingredientRaloxifene HClCat. No. P-R006-001CAS 82640-04-8

ImpurityRaloxifene EP Impurity A, N-oxideCat. No. P-R006-002

Pharmacopoeial impurityRaloxifene EP Impurity CCat. No. P-R006-003CAS 195454-31-0

MetaboliteRaloxifene-4'-Glucuronide Lithium SaltCat. No. P-R006-005

MetaboliteRaloxifene-6-Glucuronide Lithium SaltCat. No. P-R006-006

Isotopically labelledRaloxifene-d4-4'-Glucuronide Lithium SaltCat. No. P-R006-007

Isotopically labelledRaloxifene-d4-6-Glucuronide Lithium SaltCat. No. P-R006-008

ImpurityRaloxifene Impurity 1Cat. No. P-R006-009CAS 84449-65-0

Impurity4-[2-(Piperidin-1-yl)ethoxy]benzoic Acid HydrochlorideCat. No. P-R006-010CAS 84449-80-9

ImpurityRaloxifene Impurity 2Cat. No. P-R006-011CAS 63675-74-1

ImpurityMethyl 4-(2-Hydroxyethoxy)benzoateCat. No. P-R006-012CAS 3204-73-7

ImpurityRaloxifene Impurity 3Cat. No. P-R006-013CAS 89407-97-6

ImpurityRaloxifene Impurity 4Cat. No. P-R006-014

ImpurityRaloxifene Impurity 5Cat. No. P-R006-015

ImpurityRaloxifene Impurity 6Cat. No. P-R006-016

ImpurityRaloxifene Impurity 7Cat. No. P-R006-017

ImpurityRaloxifene Impurity 8Cat. No. P-R006-018

Pharmacopoeial impurityRaloxifene EP Impurity ACat. No. P-R006-020CAS 1159977-58-8

Pharmacopoeial impurityRaloxifene EP Impurity BCat. No. P-R006-021CAS 1391054-73-1

ImpurityRaloxifene 6-Monomethyl EtherCat. No. P-R006-022CAS 178451-13-3

ImpurityRaloxifene DimerCat. No. P-R006-023CAS 618902-12-8

ImpurityRaloxifene Dimesylate HydrochlorideCat. No. P-R006-024CAS 84449-85-4

ImpurityRaloxifene Dimethoxy ImpurityCat. No. P-R006-025CAS 84541-38-8

ImpurityRaloxifene Impurity 10Cat. No. P-R006-026CAS 182133-38-6

ImpurityRaloxifene Impurity 33Cat. No. P-R006-027CAS 246233-44-3

ImpurityRaloxifene Impurity 34Cat. No. P-R006-028CAS 225222-75-3

ImpurityRaloxifene Impurity 36Cat. No. P-R006-029CAS 414861-52-2

MetaboliteRaloxifene-4'-glucuronideCat. No. P-R006-030CAS 182507-22-8

MetaboliteRaloxifene-6-glucuronideCat. No. P-R006-031CAS 174264-50-7

Isotopically labelledRaloxifene-d4Cat. No. P-R006-032CAS 1185076-44-1

Isotopically labelledRaloxifene-d4 HClCat. No. P-R006-033CAS 1188263-47-9

Impurity1-(2-chloroethyl)piperidine hydrochlorideCat. No. P-R006-034CAS 2008-75-5

ImpurityRaloxifene Impurity 11Cat. No. P-R006-035CAS 63762-93-6

Impurity2,2-Dibromo-1-(4-methoxyphenyl)ethanoneCat. No. P-R006-036CAS 13664-92-1

Impurity2-(2-(piperidin-1-yl)ethoxy)benzoic acidCat. No. P-R006-037CAS 937666-17-6

Pharmacopoeial impurityRaloxifene EP Impurity DCat. No. P-R006-038CAS 177744-96-6

ImpurityRaloxifene Impurity 12Cat. No. P-R006-039CAS 1190867-20-9

ImpurityRaloxifene Impurity 13Cat. No. P-R006-040CAS 63676-22-2

Impurity2-(4-methoxyphenyl)benzo[b]thiophen-6-olCat. No. P-R006-041CAS 225648-21-5

ImpurityRaloxifene Impurity 14Cat. No. P-R006-042CAS 72232-71-4

Impurity2-Bromo-4'-methoxyacetophenoneCat. No. P-R006-043CAS 2632-13-5

Impurity2-Ethyl-1-BenzothiopheneCat. No. P-R006-044CAS 1196-81-2

ImpurityRaloxifene Impurity 15 HydrochlorideCat. No. P-R006-045CAS 84449-81-0

ImpurityRaloxifene Impurity 16Cat. No. P-R006-046CAS 767286-87-3

ImpurityRaloxifene Impurity 17Cat. No. P-R006-047CAS 414861-41-9

Impurity4-(6-methoxybenzo[b]thiophen-2-yl)phenolCat. No. P-R006-048CAS 175460-94-3

Impurity4-(piperidin-1-ylmethoxy)benzoic acidCat. No. P-R006-049CAS 938140-30-8

Impurity4-Bromophenyl methanesulfonateCat. No. P-R006-050CAS 68574-35-6

ImpurityRaloxifene Impurity 18Cat. No. P-R006-051CAS 182133-35-3

ImpurityN-PiperidinoethanolCat. No. P-R006-052CAS 3040-44-6

EDQM standards 2

The official European Pharmacopoeia standards for this family.

Structure not applicable: mixtureFor peak identificationRaloxifene for peak identification CRSEDQM code Y0001135Family Raloxifene

Reference substanceRaloxifene hydrochloride CRSEDQM code Y0001134Family Raloxifene

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