Family · Pharmaceutical analytical standards
Rodatristat
An inhibitor of tryptophan hydroxylase 1, the enzyme that makes serotonin outside the brain. Since 2019 it has been studied in phase 2 trials, as an oral prodrug called rodatristat ethyl, for pulmonary arterial hypertension. This family brings together the active ingredient, labelled standards, nitrosamines and other impurities.
Did you know?It was designed to barely cross the blood-brain barrier: the aim is to lower the serotonin made in the lungs, which drives thickening of the pulmonary arteries, while sparing the brain's serotonin.
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