Family · Pharmaceutical analytical standards
Sacubitril
A prodrug that inhibits neprilysin, the enzyme that breaks down natriuretic peptides. Combined with valsartan it forms an angiotensin receptor-neprilysin inhibitor (ARNI), approved in 2015 for heart failure. This family brings together the active ingredient, metabolites, labelled standards, nitrosamines and other impurities.
Did you know?The hormones it protects come from the heart itself: in the early 1980s Adolfo de Bold, at Queen's University in Canada, showed that the heart produces hormones, the natriuretic peptides, just like a gland.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
