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Family · Pharmaceutical analytical standards

Sacubitril

A prodrug that inhibits neprilysin, the enzyme that breaks down natriuretic peptides. Combined with valsartan it forms an angiotensin receptor-neprilysin inhibitor (ARNI), approved in 2015 for heart failure. This family brings together the active ingredient, metabolites, labelled standards, nitrosamines and other impurities.

Did you know?The hormones it protects come from the heart itself: in the early 1980s Adolfo de Bold, at Queen's University in Canada, showed that the heart produces hormones, the natriuretic peptides, just like a gland.

SacubitrilGo to the active ingredient →
SacubitrilActive ingredientSacubitrilCat. No. P-S001-001CAS 149709-62-6
Sacubitril-d4Isotopically labelledSacubitril-d4Cat. No. P-S001-010CAS 1884269-07-1

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