Family · Pharmaceutical analytical standards
Sonidegib
An oral inhibitor of the Hedgehog signalling pathway: it blocks the protein Smoothened, which when overactive drives the growth of some tumours. It was approved in 2015 in the US and the European Union for locally advanced basal cell carcinoma. This family brings together labelled standards, nitrosamines and other impurities.
Did you know?The pathway it blocks is named after a fruit fly gene: larvae lacking the Hedgehog gene, short, stubby and covered in denticles, look like a tiny hedgehog.
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