Active ingredientTesirineCat. No. P-T068-001CAS 1595275-62-9Family · Pharmaceutical analytical standards
Tesirine
A cytotoxic payload for antibody-drug conjugates (ADCs): a pyrrolobenzodiazepine dimer (SG3199) joined to a cleavable valine-alanine linker. Released inside the tumour cell, it binds the minor groove of DNA and cross-links its two strands; an ADC containing it has been approved in the United States since 2021. This family brings together the active ingredient.
Did you know?Pyrrolobenzodiazepines come from nature: the first, anthramycin, was obtained in the 1950s from the heat-loving actinomycete Streptomyces refuineus by M. D. Tendler and S. Korman.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.