Family · Pharmaceutical analytical standards
Trimethoprim
An antibacterial that blocks dihydrofolate reductase, the enzyme bacteria use to make the folates they need for their DNA. Developed in 1956 by George Hitchings' group in the United States and in use since 1962, it is mainly used for urinary infections, often together with sulfamethoxazole. This family brings together the active ingredient, pharmacopoeial impurities, labelled standards and other impurities.
Did you know?It binds the bacterial enzyme tens of thousands of times more strongly than the human one, which is why it hits microbes while sparing our cells. The name sums up its structure: trimethoxy-pyrimidine.
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EDQM standards 2
The official European Pharmacopoeia standards for this family.
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Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.
