Active ingredientMeclozineCat. No. P-M023-001CAS 569-65-3
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Impurity or related compound · Meclozine family
Pharmaceutical analytical standard1,4-bis(3-methylbenzyl)piperazinedihydrochloride
Synonyms: Meclizine Impurity 1 Dihydrochloride, Meclozine Impurity 1 Dihydrochloride, 1,4-Bis(3-methylbenzyl) piperazine dihydrochloride
- Cat. No.
- P-M023-010
- CAS
- 5321-65-3
- Alternative CAS
- 625406-13-5 (free base)
- Formula
- C20H26N2·2HCl
- Molecular weight
- 367.36 g/mol
- Category
- Impurity or related compound
Family: Meclozine
A first-generation antihistamine of the piperazine family, patented in 1951 and in use since 1953 for motion sickness, with nausea, vomiting and dizziness, and for vertigo, including that of Ménière's disease.
Did you know?It has two official names: meclozine in Italy and most of Europe, meclizine in the United States, where in 2023 it was among the most prescribed medicines, with more than 4 million prescriptions.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Meclozine family
Active ingredientMeclozineCat. No. P-M023-001CAS 569-65-3
Active ingredientMeclozine DiHClCat. No. P-M023-002CAS 1104-22-9
Active ingredientMeclozine Dihydrochloride MonohydrateCat. No. P-M023-003CAS 31884-77-2
Pharmacopoeial impurityMeclozine Dihydrochloride EP Impurity BCat. No. P-M023-004CAS 119-56-2
Pharmacopoeial impurityMeclozine EP Impurity DCat. No. P-M023-005CAS 1207847-84-4
Pharmacopoeial impurityMeclozine EP Impurity ECat. No. P-M023-006CAS 16896-82-5
Pharmacopoeial impurityMeclizine USP Related Compound BCat. No. P-M023-007
Isotopically labelledMeclozine-d8Cat. No. P-M023-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.