Active ingredientBortezomibCat. No. P-B099-001CAS 179324-69-7
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Impurity or related compound · Bortezomib family
Pharmaceutical analytical standard(1S,2S)-Bortezomib
Synonyms: Bortezomib Impurity Ps619, Bortezomib, (1S,2S)-
- Cat. No.
- P-B099-006
- CAS
- 1132709-14-8
- Alternative CAS
- N/A
- Formula
- C19H25BN4O4
- Molecular weight
- 384.24 g/mol
- Category
- Impurity or related compound
Family: Bortezomib
The first proteasome inhibitor drug, blocking the system that disposes of proteins inside cells: approved in the United States in 2003 for multiple myeloma, it is also used in mantle cell lymphoma.
Did you know?It was the first boronic acid drug ever approved: it is the boron atom itself that latches onto the active site of the proteasome and blocks it.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Bortezomib family
Active ingredientBortezomibCat. No. P-B099-001CAS 179324-69-7
Pharmacopoeial impurityBortezomib Amide AnalogCat. No. P-B099-002CAS 289472-80-6
Isotopically labelledBortezomib-d15Cat. No. P-B099-003
Pharmacopoeial impurity(1R,2R)-BortezomibCat. No. P-B099-004CAS 1132709-15-9
Impurity(1S,2R)-BortezomibCat. No. P-B099-005CAS 1132709-16-0
Impurity(R)-(1-amino-3-methylbutyl)boronic acid hydrochlorideCat. No. P-B099-007CAS 1158974-93-6
Impurity1-bromo-2-methylpropaneCat. No. P-B099-008CAS 78-77-3
Impurity1-chloro-2-methylpropaneCat. No. P-B099-009CAS 513-36-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.