Active ingredientCeritinibCat. No. P-C115-001CAS 1032900-25-6
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Impurity or related compound · Ceritinib family
Pharmaceutical analytical standard2-Chloro-4-fluoro-6-nitrotoluene
Synonyms: Ceritinib Impurity 4, 1-chloro-5-fluoro-2-methyl-3-nitrobenzene
- Cat. No.
- P-C115-007
- CAS
- 502496-35-7
- Alternative CAS
- N/A
- Formula
- C7H5ClFNO2
- Molecular weight
- 189.57 g/mol
- Category
- Impurity or related compound
Family: Ceritinib
A second-generation inhibitor of the ALK kinase, for ALK-positive non-small cell lung cancer: approved in the United States in April 2014 for patients whose disease progressed on, or who could not tolerate, crizotinib.
Did you know?Thanks to the breakthrough therapy designation it received in 2013, the FDA approved it four months ahead of the goal date for priority review.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ceritinib family
Active ingredientCeritinibCat. No. P-C115-001CAS 1032900-25-6
Isotopically labelledCeritinib-d7Cat. No. P-C115-002CAS 1632484-77-5
Isotopically labelledN-Nitroso Ceritinib-d7Cat. No. P-C115-003
NitrosamineN-Nitroso CeritinibCat. No. P-C115-004
Impurity2-Chloro-4-fluoro-3-nitrotolueneCat. No. P-C115-005CAS 1805115-44-9
Impurity2-Chloro-4-fluoro-5-nitrotolueneCat. No. P-C115-006CAS 112108-73-3
ImpurityCeritinib Impurity 1Cat. No. P-C115-008CAS 1032903-62-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.