Active ingredientTucatinibCat. No. P-T234-001CAS 937263-43-9
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Impurity or related compound · Tucatinib family
Pharmaceutical analytical standard2-(hydroxyamino)-2-methylpropan-1-ol
Synonyms: Tucatinib Impurity N5
- Cat. No.
- P-T234-006
- CAS
- 4706-13-2
- Alternative CAS
- 63829-84-5 (hydrochloride)
- Formula
- C4H11NO2
- Molecular weight
- 105.14 g/mol
- Category
- Impurity or related compound
Family: Tucatinib
A highly selective oral HER2 tyrosine kinase inhibitor, approved in the United States in 2020 for metastatic HER2-positive breast cancer, including when it has spread to the brain.
Did you know?It was the first new medicine approved under Project Orbis, in which the regulators of the United States, Australia, Canada, Singapore and Switzerland reviewed the application together.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Tucatinib family
Active ingredientTucatinibCat. No. P-T234-001CAS 937263-43-9
Isotopically labelledTucatinib Impurity 6-d4Cat. No. P-T234-002
Isotopically labelledTucatinib Impurity 8-d6Cat. No. P-T234-003
Isotopically labelledTucatinib-d6Cat. No. P-T234-004
ImpurityTucatimib intennediateCat. No. P-T234-007CAS 937263-71-3
ImpurityTucatinib Impurity 1Cat. No. P-T234-008
ImpurityTucatinib Impurity 2Cat. No. P-T234-009
ImpurityTucatinib Impurity 3Cat. No. P-T234-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.