Active ingredientMetronidazoleCat. No. P-M112-001CAS 443-48-1
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Pharmacopoeial impurity · Metronidazole family
Pharmaceutical analytical standard2-Methyl-4-nitroimidazole
Synonyms: 2-methyl-5-nitro-1H-imidazole, Menidazole, Imidazole, 2-methyl-4-nitro-, Metronidazole Impurity 19, Imidazole, 2-methyl-5-nitro-, Ornidazole metabolite m1, 2-Methyl-5-nitroimidazole, Metronidazole Impurity A CRS
- Cat. No.
- P-M112-004
- CAS
- 696-23-1
- Alternative CAS
- 88054-22-2 (alternative CAS, same compound)
- 100215-29-0 (alternative CAS, same compound)
- Formula
- C4H5N3O2
- Molecular weight
- 127.10 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Metronidazole
A nitroimidazole antimicrobial developed in France and described in 1959 as a treatment for Trichomonas vaginalis; today it is used against many protozoa and anaerobic bacteria.
Did you know?It descends from azomycin, a natural antibiotic with a nitroimidazole ring described in Japan in 1953: by modifying its structure, chemists arrived at metronidazole.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- 2-Methyl-5-NitroimidazoleBP 244
- Metronidazole impurity A CRSEP Y0000087
- Tinidazole impurity A CRSEP Y0000899
More products in the Metronidazole family
Active ingredientMetronidazoleCat. No. P-M112-001CAS 443-48-1
Active ingredientMetronidazole AcetateCat. No. P-M112-002CAS 13182-82-6
Active ingredientMetronidazole BenzoateCat. No. P-M112-003CAS 13182-89-3
Pharmacopoeial impurityMetronidazole EP Impurity BCat. No. P-M112-005CAS 3034-38-6
Pharmacopoeial impurityMetronidazole EP Impurity CCat. No. P-M112-006CAS 5006-69-9
Pharmacopoeial impurityMetronidazole EP Impurity DCat. No. P-M112-007CAS 5006-68-8
Pharmacopoeial impurityMetronidazole EP Impurity ECat. No. P-M112-008CAS 705-19-1
Pharmacopoeial impurityMetronidazole EP Impurity FCat. No. P-M112-009CAS 16156-94-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.