Active ingredientAzathioprineCat. No. P-A233-001CAS 446-86-6
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Impurity or related compound · Azathioprine family
Pharmaceutical analytical standard4,5-Dichloroimidazole
Synonyms: Azathioprine Impurity 10 (4,5-Dichloroimidazole), 4,5-dichloro-1H-imidazole
- Cat. No.
- P-A233-017
- CAS
- 15965-30-7
- Alternative CAS
- N/A
- Formula
- C3H2Cl2N2
- Molecular weight
- 136.96 g/mol
- Category
- Impurity or related compound
Family: Azathioprine
An immunosuppressant created in the late 1950s by Gertrude Elion and George Hitchings, Nobel laureates in medicine in 1988: it helps prevent transplant rejection and is used in autoimmune diseases such as rheumatoid arthritis.
Did you know?It was born as a masked form of 6-mercaptopurine, intended against cancer: British surgeon Roy Calne tested it in transplants, and in 1962 it made possible the first successful kidney transplant between unrelated people.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Azathioprine family
Active ingredientAzathioprineCat. No. P-A233-001CAS 446-86-6
Pharmacopoeial impurityThiamiprineCat. No. P-A233-002CAS 5581-52-2
Pharmacopoeial impurityAzathioprine EP Impurity ACat. No. P-A233-003CAS 4531-54-8
Pharmacopoeial impurityAzathioprine EP Impurity CCat. No. P-A233-004CAS 4897-25-0
Pharmacopoeial impurityAzathioprine EP Impurity DCat. No. P-A233-005CAS 6339-54-4
Pharmacopoeial impurityAzathioprine EP Impurity E Sodium Salt (90%)Cat. No. P-A233-006CAS 35681-68-6
Isotopically labelledAzathioprine EP Impurity F-13C-15N2Cat. No. P-A233-008CAS 244769-71-9
NitrosamineN-Nitroso AzathioprineCat. No. P-A233-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.