Active ingredientIvacaftorCat. No. P-I107-001CAS 873054-44-5
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Impurity or related compound · Ivacaftor family
Pharmaceutical analytical standard5-Amino-2,4-di-tert-butylphenol
Synonyms: Phenol, 5-amino-2,4-bis(1,1-dimethylethyl)-
- Cat. No.
- P-I107-020
- CAS
- 873055-58-4
- Alternative CAS
- 1777786-05-6 (hydrochloride)
- Formula
- C14H23NO
- Molecular weight
- 221.34 g/mol
- Category
- Impurity or related compound
Family: Ivacaftor
A CFTR protein potentiator approved in the United States in 2012: it was the first medicine to act on the cause of cystic fibrosis rather than only its symptoms, helping the faulty chloride channel stay open.
Did you know?Its development was partly funded by the US cystic fibrosis patients' foundation, with 150 million dollars: in 2014 the rights received in return were sold for 3.3 billion, reinvested in research.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ivacaftor family
Active ingredientIvacaftorCat. No. P-I107-001CAS 873054-44-5
MetaboliteIvacaftor N-glucuronideCat. No. P-I107-002
Isotopically labelledIvacaftor Impurity 7-13C2-d6Cat. No. P-I107-003
Isotopically labelledIvacaftor Impurity 7-d6Cat. No. P-I107-004
Isotopically labelledIvacaftor-d18Cat. No. P-I107-006CAS 1413431-05-6
Isotopically labelledIvacaftor-d19Cat. No. P-I107-007
NitrosamineN-Nitroso IvacaftorCat. No. P-I107-008
NitrosamineN-Nitroso Ivacaftor Impurity 1Cat. No. P-I107-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.