Active ingredientPalonosetronCat. No. P-P006-001CAS 135729-61-2
Drag to rotate
Impurity or related compound · Palonosetron family
Pharmaceutical analytical standard(6S)-Hydroxy (S,S)-Palonosetron
Synonyms: Palonosetron metabolite M4, Palonosetron metabolite (6-S-hydroxy-palonosetron), Palonosetron (6S)-Hydroxy (S,S)-Isomer
- Cat. No.
- P-P006-013
- CAS
- 848074-08-8
- Alternative CAS
- N/A
- Formula
- C19H24N2O2
- Molecular weight
- 312.41 g/mol
- Category
- Impurity or related compound
Family: Palonosetron
A serotonin 5-HT3 receptor antagonist, approved in the United States in 2003 to prevent nausea and vomiting caused by chemotherapy, including the delayed phase in the following days.
Did you know?Its half-life is about 40 hours, very long for its class, and in about one patient in ten it exceeds 100 hours: a single administration thus also covers the days after treatment.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Palonosetron family
Active ingredientPalonosetronCat. No. P-P006-001CAS 135729-61-2
Active ingredientPalonosetron HydrochlorideCat. No. P-P006-002CAS 135729-62-3
Pharmacopoeial impurityPalonosetron USP Related Compound ACat. No. P-P006-003CAS 813425-83-1
Pharmacopoeial impurityPalonosetron USP Related Compound BCat. No. P-P006-004CAS 1021456-82-5
Pharmacopoeial impurityPalonosetron USP Related Compound C HydrochlorideCat. No. P-P006-005CAS 135729-76-9
Pharmacopoeial impurityPalonosetron USP Related Compound D HydrochlorideCat. No. P-P006-006CAS 135755-51-0
Pharmacopoeial impurityPalonosetron USP Related Compound E HydrochlorideCat. No. P-P006-007CAS 135729-55-4
Isotopically labelledPalonosetron-d3 HClCat. No. P-P006-008CAS 1246816-81-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.