Active ingredientClozapineCat. No. P-C231-001CAS 5786-21-0
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Impurity or related compound · Clozapine family
Pharmaceutical analytical standard7-Hydroxyl Clozapine
Synonyms: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepin-7-ol
- Cat. No.
- P-C231-024
- CAS
- 355004-92-1
- Alternative CAS
- N/A
- Formula
- C18H19ClN4O
- Molecular weight
- 342.83 g/mol
- Category
- Impurity or related compound
Family: Clozapine
An antipsychotic synthesised in Switzerland in 1958 and the founder of the atypical antipsychotics; approved in the United States in 1989, it is reserved for schizophrenia that does not respond to other treatments.
Did you know?At first many psychiatrists doubted it worked, because it did not cause stiffness and tremor: a true antipsychotic was believed to need them. This very difference is why it was called 'atypical'.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Clozapine family
Active ingredientClozapineCat. No. P-C231-001CAS 5786-21-0
Pharmacopoeial impurityClozapine EP Impurity ACat. No. P-C231-002CAS 50892-62-1
Pharmacopoeial impurityClozapine EP Impurity BCat. No. P-C231-003CAS 263366-81-0
Pharmacopoeial impurityClozapine EP Impurity CCat. No. P-C231-004CAS 6104-71-8
Pharmacopoeial impurityClozapine EP Impurity C HCl SaltCat. No. P-C231-005CAS 2741767-92-8
Pharmacopoeial impurityClozapine EP Impurity DCat. No. P-C231-006CAS 65514-71-8
MetaboliteClozapine N-GlucuronideCat. No. P-C231-008CAS 165602-86-8
MetaboliteClozapine-5-N-Glucuronide Sodium SaltCat. No. P-C231-010CAS 390651-03-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.