Active ingredientAcemetacinCat. No. P-A016-001CAS 53164-05-9
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Pharmacopoeial impurity · Acemetacin family
Pharmaceutical analytical standardAcemetacin EP Impurity F
Synonyms: Carboxymethyl acemetacin
- Cat. No.
- P-A016-006
- CAS
- 76812-49-2
- Alternative CAS
- N/A
- Formula
- C23H20ClNO8
- Molecular weight
- 473.86 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Acemetacin
A non-steroidal anti-inflammatory drug of the indoleacetic acid family, a close relative of indometacin: patented in Germany in 1972, it has been used in Europe since the 1980s for arthritis, osteoarthritis and musculoskeletal pain.
Did you know?Chemically it is indometacin with a small glycolic acid 'tail' attached as an ester: in the body this is partly removed, releasing the parent molecule.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
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Active ingredientAcemetacinCat. No. P-A016-001CAS 53164-05-9
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Pharmacopoeial impurityAcemetacin EP Impurity CCat. No. P-A016-003
Pharmacopoeial impurityAcemetacin EP Impurity DCat. No. P-A016-004CAS 76812-64-1
Pharmacopoeial impurityAcemetacin EP Impurity ECat. No. P-A016-005CAS 75302-98-6
MetaboliteAcemetacin-Acyl-beta-D-GlucuronideCat. No. P-A016-007CAS 1260603-31-3
Isotopically labelledAcemetacin-d4Cat. No. P-A016-008CAS 1196151-16-2
Impurity2-(4-chlorobenzoyl)oxyacetic acidCat. No. P-A016-009CAS 10414-67-2Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.