Active ingredientAlectinibCat. No. P-A069-001CAS 1256580-46-7
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Impurity or related compound · Alectinib family
Pharmaceutical analytical standardAlectinib Impurity 14 Trifluoroacetate
Synonyms: 9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carboxamide trifluoroacetate
- Cat. No.
- P-A069-028
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C30H36N4O3·C2HF3O2
- Molecular weight
- 614.67 g/mol
- Category
- Impurity or related compound
Family: Alectinib
An ALK kinase inhibitor for ALK-positive non-small cell lung cancer: first approved in Japan in 2014, in the United States in 2015 and in Europe in 2017.
Did you know?It reaches the brain well because it is not pumped out by P-glycoprotein, the pump that guards the blood-brain barrier: this is why it is also active against brain metastases.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Alectinib family
Active ingredientAlectinibCat. No. P-A069-001CAS 1256580-46-7
Active ingredientAlectinib HydrochlorideCat. No. P-A069-002CAS 1256589-74-8
MetaboliteAlectinib M1a MetaboliteCat. No. P-A069-003
MetaboliteAlectinib M1b MetaboliteCat. No. P-A069-004
MetaboliteAlectinib M4 MetaboliteCat. No. P-A069-005CAS 1256585-04-2
Isotopically labelledAlectinib Impurity 19-d6Cat. No. P-A069-006
Isotopically labelledAlectinib M4 Metabolite-d6Cat. No. P-A069-007
Isotopically labelledAlectinib-d5Cat. No. P-A069-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.