MetaboliteAllopregnanolone GlucuronideCat. No. P-A081-002CAS 31300-86-4
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Active ingredient · Allopregnanolone family
Pharmaceutical analytical standardAllopregnanolone
Synonyms: Brexanolone, Allotetrahydroprogesterone, Allopregnan-3alpha-ol-20-one, Brexanolona, DEA NO. 2400, Pregnan-20-one, 3-hydroxy-, (3-alpha,5-alpha)-, Pregnanolone, (3alpha,5alpha)-, Zulresso, Tetrahydroprogesterone, Allopregnan-3a-ol-20-one, Brexanolonum, Allopregnalone, Pregnan-20-one, 3-hydroxy-, (3a,5a)-, Brexanolone (USAN/INN), Pregnane-3alpha-ol-20-one, 5alpha-
- Cat. No.
- P-A081-001
- CAS
- 516-54-1
- Alternative CAS
- N/A
- Formula
- C21H34O2
- Molecular weight
- 318.50 g/mol
- Category
- Active ingredient (API)
A natural neurosteroid the body makes from progesterone: it enhances GABA-A receptors, the brain's main 'braking' system. As a medicine, also known as brexanolone, it was approved in the US in 2019 as the first drug approved specifically for postpartum depression.
Did you know?It also has a role before birth: it contributes to the sedation of the fetus in the womb and is a step in the 'backdoor' pathway of androgen synthesis, important for the development of the male fetus.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Allopregnanolone family
MetaboliteAllopregnanolone GlucuronideCat. No. P-A081-002CAS 31300-86-4
Isotopically labelledAllopregnanolone Impurity 2-d5Cat. No. P-A081-003
Isotopically labelledAllopregnanolone-d3 Diol MetaboliteCat. No. P-A081-005
Isotopically labelledAllopregnanolone-d3 GlucuronideCat. No. P-A081-006
Isotopically labelledAllopregnanolone-d4Cat. No. P-A081-007CAS 203805-85-0
Isotopically labelledAllopregnanolone-d4 GlucuronideCat. No. P-A081-008
Isotopically labelled(3beta)-Allopregnanolone-d4 Sulfate Sodium SaltCat. No. P-A081-009
Isotopically labelledAllopregnanolone-d5Cat. No. P-A081-010CAS 2687960-66-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.