Pharmacopoeial impurityAmitriptyline EP Impurity ACat. No. P-A134-002CAS 1210-35-1
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Active ingredient · Amitriptyline family
Pharmaceutical analytical standardAmitriptyline Hydrochloride
Synonyms: Etravil, Syneudon, Novoprotect, Amitid, Amitril, Saroten Retard, Cytriptyline, Triptafen-m, Annoyltin, Domical, Endep, Elavil hydrochloride, Amineurin, Lentizol, Saroten, Amavil, Ami-Anelun, Anapsique, Daprimen, Elatrolet, Maxivalet, Miketorin, Mitaptyline, Rantoron, Sarotena, Trepiline, Triptizol, Tryptine, Trytomer, Vanatrip, Yamanouchi, Amilit, Amiplin, Amiprin, Amitrip, Amyline, Amyzol, Belpax, Elatrol, Enafon, Etrafon, Kyliran, Larozyl, Levate, Pinsanu, Pinsaun, Teperin, Triavil, Tridep, Tripta, Trynol, Damilen hydrochloride, Tryptizol retard, Limbitrol DS, Tryptacap hydrochloride, ADT-Zimaia, Oasil-M, Limbitrol, Proheptadien monohydrochloride, Amitryptiline hydrochloride, Annolytin, Component of Etrafon, Component of Triavil, Novotriptyn, Nornaln, Amitryptyline hydrochloride, Amilent, Sylvemid, Amicen, Euplit, Uxen, Amitryptylline HCl, Elavil, Nortriptyline EP Impurity F Hydrochloride, Nortriptyline Impurity F
- Cat. No.
- P-A134-001
- CAS
- 549-18-8
- Alternative CAS
- 50-48-6 (free base)
- 30227-34-0 (maleate)
- Formula
- C20H23N·HCl
- Molecular weight
- 313.87 g/mol
- Category
- Active ingredient (API)
A tricyclic antidepressant discovered in the late 1950s and approved in the United States in 1961; it is used for depression and also for neuropathic pain and migraine prevention.
Did you know?The name 'tricyclic' comes from the three fused rings in its structure; amitriptyline is on the World Health Organization's List of Essential Medicines.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Amitriptyline HydrochlorideBP 016
- Amitriptyline hydrochloride CRSEP Y0000563
More products in the Amitriptyline family
Pharmacopoeial impurityAmitriptyline EP Impurity ACat. No. P-A134-002CAS 1210-35-1
Pharmacopoeial impurityAmitriptyline EP Impurity B HydrochlorideCat. No. P-A134-003CAS 6202-23-9
Pharmacopoeial impurityAmitriptyline EP Impurity DCat. No. P-A134-004CAS 1159-03-1
Pharmacopoeial impurityAmitriptyline EP Impurity E HCl (Mixture of Diastereomers)Cat. No. P-A134-005
Pharmacopoeial impurityAmitriptyline EP Impurity GCat. No. P-A134-007CAS 1210-34-0
Pharmacopoeial impurityAmitriptyline Hydrochloride EP Impurity FCat. No. P-A134-008CAS 1159-82-6
MetaboliteAmitriptyline N-GlucuronideCat. No. P-A134-009CAS 112806-33-4
Isotopically labelledAmitriptyline EP Impurity F-d6Cat. No. P-A134-010Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
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