Active ingredientAmorolfine HClCat. No. P-A141-001CAS 78613-38-4
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Pharmacopoeial impurity · Amorolfine family
Pharmaceutical analytical standardAmorolfine EP Impurity K
- Cat. No.
- P-A141-009
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C22H37NO
- Molecular weight
- 331.54 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Amorolfine
An antifungal of the morpholine class, used mainly as a 5% medicated nail lacquer for onychomycosis, fungal nail infection. First launched in the United Kingdom in 1991, it was later authorised in several countries for sale without a prescription.
Did you know?It blocks two different enzymes in the production of ergosterol, the main sterol of fungal membranes, so ignosterol builds up instead: against most species it is fungicidal, killing the fungus rather than just halting it.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Amorolfine family
Active ingredientAmorolfine HClCat. No. P-A141-001CAS 78613-38-4
Pharmacopoeial impurityAmorolfine EP Impurity ACat. No. P-A141-002CAS 78613-39-5
Pharmacopoeial impurityAmorolfine EP Impurity BCat. No. P-A141-003CAS 142347-84-0
Pharmacopoeial impurityAmorolfine EP Impurity DCat. No. P-A141-004CAS 67564-91-4
Pharmacopoeial impurityAmorolfine EP Impurity E HCl (Mixture of Diastereomers)Cat. No. P-A141-005
Pharmacopoeial impurityAmorolfine EP Impurity FCat. No. P-A141-006CAS 106614-66-8
Pharmacopoeial impurityAmorolfine EP Impurity GCat. No. P-A141-007CAS 1260498-34-7
Pharmacopoeial impurityAmorolfine EP Impurity I HClCat. No. P-A141-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.