Active ingredientAnastrozoleCat. No. P-A155-001CAS 120511-73-1
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Impurity or related compound · Anastrozole family
Pharmaceutical analytical standardAnastrozole Carboxylic Acid
Synonyms: 3,5-Bis(1-cyano-1-methylethyl)benzoic Acid, 3,5-Bis(2-cyanopropan-2-yl)benzoic acid, Anastrozole Carboxylic Acid (3,5-Bis(1-cyano-1-methylethyl)benzoic Acid)
- Cat. No.
- P-A155-017
- CAS
- 1085181-50-5
- Alternative CAS
- N/A
- Formula
- C15H16N2O2
- Molecular weight
- 256.31 g/mol
- Category
- Impurity or related compound
Family: Anastrozole
A non-steroidal aromatase inhibitor, approved in the United States in 1995 for hormone-sensitive breast cancer in postmenopausal women: it blocks the enzyme that turns androgens into oestrogens.
Did you know?After menopause, oestrogens no longer come mainly from the ovaries but from tissues such as subcutaneous fat, muscle and liver, where aromatase makes them from androgens: this is the source anastrozole switches off.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Anastrozole family
Active ingredientAnastrozoleCat. No. P-A155-001CAS 120511-73-1
Pharmacopoeial impurityAnastrozole EP Impurity ACat. No. P-A155-002CAS 1215780-15-6
Pharmacopoeial impurityAnastrozole EP Impurity BCat. No. P-A155-003CAS 1216898-82-6
Pharmacopoeial impurityAnastrozole EP Impurity CCat. No. P-A155-004CAS 120511-84-4
Pharmacopoeial impurityAnastrozole EP Impurity DCat. No. P-A155-005CAS 1027160-12-8
Pharmacopoeial impurityAnastrozole EP Impurity ECat. No. P-A155-006CAS 120511-88-8
Pharmacopoeial impurityAnastrozole EP Impurity GCat. No. P-A155-007CAS 120511-92-4
Pharmacopoeial impurityAnastrozole EP Impurity HCat. No. P-A155-008CAS 120511-72-0Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.