Active ingredientApixabanCat. No. P-A172-001CAS 503612-47-3
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Impurity or related compound · Apixaban family
Pharmaceutical analytical standardApixaban Impurity 26
Synonyms: 6-[4-(5-Chloropentanoylamino)phenyl]-7-oxo-1-phenyl-4,5-dihydropyrazolo[5,4-c]pyridine-3-carboxamide
- Cat. No.
- P-A172-059
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C24H24ClN5O3
- Molecular weight
- 465.94 g/mol
- Category
- Impurity or related compound
Family: Apixaban
An oral anticoagulant that directly inhibits coagulation factor Xa, approved in Europe in 2011. It is used to prevent strokes and thrombosis, for example in atrial fibrillation and after hip or knee replacement.
Did you know?Only about a quarter of the dose is cleared by the kidneys: among the new oral anticoagulants it is the one that depends least on kidney function.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Apixaban family
Active ingredientApixabanCat. No. P-A172-001CAS 503612-47-3
Pharmacopoeial impurityApixaban USP Related Compound DCat. No. P-A172-002CAS 1351611-14-7
Pharmacopoeial impurityApixaban USP Related Compound GCat. No. P-A172-003CAS 881386-12-5
Pharmacopoeial impurityApixaban USP Related Compound HCat. No. P-A172-004CAS 1421823-20-2
Isotopically labelledApixaban Amino Acid Impurity-13C-d3Cat. No. P-A172-005
Isotopically labelledApixaban-13C-d3Cat. No. P-A172-006CAS 1261393-15-0
Isotopically labelledN-Nitroso Apixaban Amino Acid Impurity-13C-d3Cat. No. P-A172-007
NitrosamineN-Nitroso Apixaban Impurity 1Cat. No. P-A172-008Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.