Impurity or related compound · Aprotinin family
Pharmaceutical analytical standardAprotinin Solution BRP
Synonyms: Pancreatic trypsin inhibitor, Aprotininum, Aprotinin, BPTI, Antilysine, Aprotinina, Aprotinine, Antikrein, Onquinin, Pantinol, Protimbin, Repulson, Trascolan, Fosten, Tzalol, Kir richter, Aprotinin bovine, Basic protease inhibitor, Kallikrein-trypsin inactivator, Basic pancreatic trypsin inhibitor, Pancreatic basic trypsin inhibitor, Pancreatic trypsin inhibitor (kunitz), Bovine Aprotinin, TachoComb H, Aprotinin Biosynthetic, Fibrinolysis Inhibitor, Inactivator, Kallikrein-Trypsin, Bovine Pancreatic Trypsin Inhibitor, Kunitz Pancreatic Trypsin Inhibitor, Trypsin Inhibitor, Basic, Pancreatic, Trypsin Inhibitor, Kunitz, Pancreatic, BPTI, Basic Pancreatic Trypsin Inhibitor, Bovine Kunitz Pancreatic Trypsin Inhibitor, Trypsin Inhibitor, Pancreatic Basic, Trasylol, Iniprol, Trazinin, Zymofren, Antagosan, Contrykal, Gordox, Basic protease inhibitor (BPI), Trypsin-kallikrein inhibitor (kunitz), RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
- Cat. No.
- P-A178-002
- CAS
- 9087-70-1
- Alternative CAS
- N/A
- Formula
- C284H432N84O79S7
- Molecular weight
- 6511.51 g/mol
- Category
- Impurity or related compound
Family: Aprotinin
A small 58-amino-acid polypeptide that inhibits trypsin and other proteases, first isolated in 1930 from bovine glands and used since the 1960s to reduce bleeding in surgery, especially heart surgery.
Did you know?Also known as BPTI, it is one of the most studied proteins ever: in 1977 it was the first to be simulated on a computer with molecular dynamics, and it was the first whose structure was solved by NMR.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- Aprotinin for system suitability CRSEP Y0001154
- Aprotinin solution BRPEP A1250000
More products in the Aprotinin family
Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.