MetaboliteAtaluren acyl glucuronideCat. No. P-A203-002
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Active ingredient · Ataluren family
Pharmaceutical analytical standardAtaluren
Synonyms: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid, Translarna, Benzoic acid, 3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl)-
- Cat. No.
- P-A203-001
- CAS
- 775304-57-9
- Alternative CAS
- 775304-59-1 (sodium salt)
- Formula
- C15H9FN2O3
- Molecular weight
- 284.25 g/mol
- Category
- Active ingredient (API)
A small oral molecule designed to make ribosomes read through premature stop codons caused by nonsense mutations; in 2014 it received conditional authorisation in the European Union for Duchenne muscular dystrophy due to these mutations, which the EMA recommended not renewing in 2024.
Did you know?It was found to bind and stabilise luciferase, the enzyme that makes fireflies glow and is used in many laboratory tests: an effect that can skew assays based on this light.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Ataluren family
MetaboliteAtaluren acyl glucuronideCat. No. P-A203-002
Isotopically labelledAtaluren-d4Cat. No. P-A203-003CAS 1922064-61-6
ImpurityAtaluren Impurity 1Cat. No. P-A203-004CAS 775304-03-5
ImpurityAtaluren Impurity NCat. No. P-A203-005CAS 775304-56-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.