Active ingredientAtogepantCat. No. P-A208-001CAS 1374248-81-3
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Stable isotope labelled · Atogepant family
Pharmaceutical analytical standardAtogepant-d4
Synonyms: Spiro Ring-d4
- Cat. No.
- P-A208-002
- CAS
- N/A
- Alternative CAS
- 1374248-81-3 (unlabelled form)
- Formula
- C29H19D4F6N5O3
- Molecular weight
- 607.55 g/mol
- Category
- Stable isotope labelled
Family: Atogepant
A gepant, that is an oral antagonist of the receptor for CGRP, a key molecule in migraine attacks: it is taken every day to prevent them. Approved in the United States in September 2021 and in the European Union in August 2023.
Did you know?CGRP was discovered by chance in the early 1980s by researchers studying thyroid tumours: it is made from the same gene as calcitonin, hence the name "calcitonin gene-related peptide".
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Atogepant family
Active ingredientAtogepantCat. No. P-A208-001CAS 1374248-81-3
ImpurityAtogepant Impurity 1Cat. No. P-A208-003CAS 1456803-42-1
ImpurityAtogepant Impurity 2Cat. No. P-A208-004
ImpurityAtogepant Impurity 3 (Atogepant Enantiomer)Cat. No. P-A208-005CAS 2733814-47-4
ImpurityAtogepant Impurity 4Cat. No. P-A208-006
ImpurityAtogepant Impurity 5Cat. No. P-A208-007
ImpurityAtogepant Impurity 6Cat. No. P-A208-008CAS 1488326-89-1Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.