Active ingredientAvatrombopagCat. No. P-A221-001CAS 570406-98-3
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Impurity or related compound · Avatrombopag family
Pharmaceutical analytical standardAvatrombopag Impurity 29
Synonyms: N-[5-Bromo-4-(4-chlorothiophen-2-yl)-1,3-thiazol-2-yl]-5,6-dichloropyridine-3-carboxamide
- Cat. No.
- P-A221-035
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C13H5BrCl3N3OS2
- Molecular weight
- 469.58 g/mol
- Category
- Impurity or related compound
Family: Avatrombopag
An oral thrombopoietin receptor agonist that stimulates platelet production; approved in the United States in May 2018 for adults with chronic liver disease and low platelets who are scheduled for a procedure.
Did you know?It mimics thrombopoietin, the hormone that controls platelet production and is made mainly by the liver: this is why platelets often fall in chronic liver disease.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Avatrombopag family
Active ingredientAvatrombopagCat. No. P-A221-001CAS 570406-98-3
Isotopically labelledAvatrombopag-d8 HClCat. No. P-A221-002
Impurity3-Hydroxy-avatrombopagCat. No. P-A221-003CAS 1290121-42-4
ImpurityAvatrombopag Impurity 1Cat. No. P-A221-004CAS 959042-70-7
ImpurityAvatrombopag Impurity 2Cat. No. P-A221-005CAS 570407-42-0
ImpurityAvatrombopag Impurity 3Cat. No. P-A221-006CAS 570407-10-2
ImpurityAvatrombopag Impurity 4Cat. No. P-A221-007CAS 1534575-19-3
ImpurityAvatrombopag Impurity 5Cat. No. P-A221-008CAS 123971-45-9Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.