Active ingredientBaclofenCat. No. P-B002-001CAS 1134-47-0
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Pharmacopoeial impurity · Baclofen family
Pharmaceutical analytical standardBaclofen EP Impurity D
Synonyms: 3-(4-Chlorophenyl)glutaric Acid, 3-(4-Chlorophenyl) glutarate, Pentanedioic acid, 3-(4-chlorophenyl)-, b-(4-Chlorophenyl) glutaric acid, b-(p-Chlorophenyl)glutaric acid, 3-(4-chlorophenyl)pentanedioic acid
- Cat. No.
- P-B002-019
- CAS
- 35271-74-0
- Alternative CAS
- N/A
- Formula
- C11H11ClO4
- Molecular weight
- 242.66 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Baclofen
A muscle relaxant that stimulates GABA-B receptors in the nervous system, synthesised in Switzerland in 1962 by chemist Heinrich Keberle: it is used to reduce spasticity, for example in multiple sclerosis and spinal cord injury.
Did you know?It was designed as a treatment for epilepsy: results there were disappointing, but it was noticed that spasticity decreased in some patients.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
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Active ingredientBaclofenCat. No. P-B002-001CAS 1134-47-0
Pharmacopoeial impurityBaclofen EP Impurity ACat. No. P-B002-003CAS 22518-27-0
Pharmacopoeial impurityBaclofen EP Impurity BCat. No. P-B002-004CAS 1141-23-7
Pharmacopoeial impurityBaclofen EP Impurity C (Mixture of Diastereomers)Cat. No. P-B002-005CAS 2726264-10-2
Pharmacopoeial impurityBaclofen EP Impurity ECat. No. P-B002-006CAS 84803-46-3
Pharmacopoeial impurityBaclofen EP Impurity FCat. No. P-B002-007CAS 4846-95-1
Pharmacopoeial impurityBaclofen EP Impurity G HClCat. No. P-B002-008CAS 947583-11-1
Pharmacopoeial impurityBaclofen EP Impurity HCat. No. P-B002-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.