Active ingredientBaricitinibCat. No. P-B011-001CAS 1187594-09-7
Drag to rotate
Impurity or related compound · Baricitinib family
Pharmaceutical analytical standardBaricitinib Impurity 27
Synonyms: 2-[3-[4-[2-[1-[3-(Cyanomethyl)-1-ethylsulfonylazetidin-3-yl]pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrazol-1-yl]-1-ethylsulfonylazetidin-3-yl]acetonitrile
- Cat. No.
- P-B011-041
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C26H29N11O4S2
- Molecular weight
- 623.71 g/mol
- Category
- Impurity or related compound
Family: Baricitinib
A Janus kinase (JAK1 and JAK2) inhibitor, approved in Europe in 2017 for rheumatoid arthritis; in the United States it was later also authorised for severe alopecia areata and for some patients hospitalised with COVID-19.
Did you know?In February 2020 an artificial intelligence system linking information mined from the scientific literature flagged it as a possible treatment for COVID-19: the hypothesis was published in The Lancet.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Baricitinib family
Active ingredientBaricitinibCat. No. P-B011-001CAS 1187594-09-7
Isotopically labelledBaricitinib-d5Cat. No. P-B011-002CAS 1564241-79-7
NitrosamineN-Nitroso Baricitinib Impurity 1Cat. No. P-B011-003
ImpurityBaricitinib Impurity 1Cat. No. P-B011-004CAS 1029716-44-6
Impurity1-(1-Ethoxyethyl)pyrazole-4-boronic AcidCat. No. P-B011-005CAS 2227194-01-4
Impurity1-(3-aminopropyl)azepan-2-oneCat. No. P-B011-006CAS 24566-95-8
Impurity1-(Ethylsulfonyl)azetidin-3-oneCat. No. P-B011-007CAS 1401222-91-0
Impurity1H-Pyrazol-4-olCat. No. P-B011-008CAS 4843-98-5Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.