Active ingredientBictegravirCat. No. P-B077-001CAS 1611493-60-7
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Impurity or related compound · Bictegravir family
Pharmaceutical analytical standardBictegravir 13 aS isomer
- Cat. No.
- P-B077-008
- CAS
- N/A
- Alternative CAS
- N/A
- Formula
- C21H18F3N3O5
- Molecular weight
- 449.39 g/mol
- Category
- Impurity or related compound
Family: Bictegravir
An HIV integrase inhibitor, blocking the enzyme the virus uses to insert its genetic material into the cell's DNA. Approved in 2018 in the United States and Europe, it comes in a single tablet together with emtricitabine and tenofovir alafenamide.
Did you know?Unlike some earlier integrase inhibitors such as elvitegravir, it does not need a pharmacokinetic booster such as ritonavir or cobicistat to keep effective levels in the blood.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Bictegravir family
Active ingredientBictegravirCat. No. P-B077-001CAS 1611493-60-7
Active ingredientBictegravir SodiumCat. No. P-B077-002CAS 1807988-02-8
MetaboliteBictegravir Metabolite 1Cat. No. P-B077-003CAS 2365156-60-9
Isotopically labelledBictegravir-D5Cat. No. P-B077-005
Impurity2,4,6-TrifluorobenzylamineCat. No. P-B077-007CAS 214759-21-4
ImpurityBictegravir 2,4-Difluoro ImpurityCat. No. P-B077-009CAS 1611493-56-1
ImpurityBictegravir EnantiomerCat. No. P-B077-010CAS 1616340-12-5
ImpurityBictegravir Impurity 1Cat. No. P-B077-012CAS 2411506-35-7Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.