Active ingredientBosentanCat. No. P-B100-001CAS 147536-97-8
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Pharmacopoeial impurity · Bosentan family
Pharmaceutical analytical standardBosentan USP Related Compound D
Synonyms: Bosentan Related Compound 1, 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine, 4,6-dichloro-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidine, Bosentan USP RC D
- Cat. No.
- P-B100-006
- CAS
- 150728-13-5
- Alternative CAS
- N/A
- Formula
- C15H10Cl2N4O2
- Molecular weight
- 349.17 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Bosentan
A dual endothelin receptor antagonist (ETA and ETB), approved in the United States in 2001: it is taken by mouth and used to treat pulmonary arterial hypertension.
Did you know?Its target, endothelin, a powerful vasoconstrictor peptide made by the cells lining blood vessels, was only discovered in 1988 by Masashi Yanagisawa, then a graduate student at the University of Tsukuba.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Bosentan family
Active ingredientBosentanCat. No. P-B100-001CAS 147536-97-8
Active ingredientBosentan MonohydrateCat. No. P-B100-002CAS 157212-55-0
Pharmacopoeial impurityBosentan USP Related Compound ACat. No. P-B100-003CAS 150727-06-3
Pharmacopoeial impurityBosentan USP Related Compound BCat. No. P-B100-004CAS 174227-14-6
Pharmacopoeial impurityBosentan USP Related Compound CCat. No. P-B100-005CAS 1097263-60-9
Pharmacopoeial impurityBosentan USP Related Compound ECat. No. P-B100-007CAS 6292-59-7
Isotopically labelledBosentan-d4Cat. No. P-B100-008CAS 1065472-77-6
ImpurityDesmethyl BosentanCat. No. P-B100-009CAS 253688-61-8Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.