Active ingredientCalcifediolCat. No. P-C007-001CAS 19356-17-3
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Pharmacopoeial impurity · Calcifediol family
Pharmaceutical analytical standardCalcifediol EP Impurity D
- Cat. No.
- P-C007-006
- CAS
- 1233749-00-2
- Alternative CAS
- 36149-00-5 (alternative CAS, same compound)
- Formula
- C27H44O2
- Molecular weight
- 400.65 g/mol
- Category
- Pharmacopoeial impurity (EP/USP)
Family: Calcifediol
It is 25-hydroxyvitamin D3, the form into which the liver converts vitamin D before the kidney activates it into calcitriol. Identified in 1968 in Hector DeLuca's laboratory in the United States, it is also used as a medicine for vitamin D deficiency and some disorders of calcium metabolism.
Did you know?It is the very molecule measured by the vitamin D blood test: it stays in circulation for weeks, with a half-life of about 15-30 days, so it is the most faithful mirror of our stores.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Calcifediol family
Active ingredientCalcifediolCat. No. P-C007-001CAS 19356-17-3
Active ingredientCalcifediol MonohydrateCat. No. P-C007-002CAS 63283-36-3
Pharmacopoeial impurityCalcifediol EP Impurity ACat. No. P-C007-003CAS 61585-29-3
Pharmacopoeial impurityCalcifediol EP Impurity BCat. No. P-C007-004CAS 22145-68-2
Pharmacopoeial impurityCalcifediol EP Impurity CCat. No. P-C007-005CAS 39932-44-0
Isotopically labelledCalcifediol-d3Cat. No. P-C007-007CAS 140710-94-7
Isotopically labelledCalcifediol-d6Cat. No. P-C007-008CAS 78782-98-6
Impurity3-O-tert-Butyldimethylsilyl CalcifediolCat. No. P-C007-009CAS 140710-90-3Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.