Pharmacopoeial impurityCalcium Levofolinate EP Impurity I Disodium SaltCat. No. P-L051-002
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Stable isotope labelled · Levofolinate family
Pharmaceutical analytical standardCalcium Levofolinate-13C5
- Cat. No.
- P-L051-003
- CAS
- N/A
- Alternative CAS
- 68538-85-2 (unlabelled form)
- 80433-71-2 (unlabelled form)
- 2060570-47-8 (unlabelled form)
- 419573-16-3 (unlabelled form, hydrate)
- 1141892-29-6 (unlabelled form, sodium salt)
- Formula
- C15¹³C5H23N7O7
- Molecular weight
- 478.41 g/mol
- Category
- Stable isotope labelled
Family: Levofolinate
The active (6S, levorotatory) form of folinic acid, a derivative of folic acid: it protects healthy cells after high doses of methotrexate and boosts fluorouracil against colorectal cancer. It was approved in the United States in 2008.
Did you know?Folinic acid was discovered in 1948 as a growth factor the bacterium Leuconostoc citrovorum cannot do without: that is why it was first called 'citrovorum factor'.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
More products in the Levofolinate family
Pharmacopoeial impurityCalcium Levofolinate EP Impurity I Disodium SaltCat. No. P-L051-002Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.