Pharmacopoeial impurityCapecitabine EP Impurity ACat. No. P-C024-002CAS 66335-38-4
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Active ingredient · Capecitabine family
Pharmaceutical analytical standardCapecitabine
Synonyms: Xeloda, Capecitibine, Capiibine, Capecytabine, Ecansya, Captabin, N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine, Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester, Pentyl (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate, Pentyl N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate, Pentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate, Caxeta, Xabine, Cytidine, 5'-deoxy-5-fluoro-N-((pentyloxy)carbonyl)-, Xeliri component capecitibine
- Cat. No.
- P-C024-001
- CAS
- 154361-50-9
- Alternative CAS
- 958887-39-3 (alternative CAS, same compound)
- Formula
- C15H22FN3O6
- Molecular weight
- 359.35 g/mol
- Category
- Active ingredient (API)
An oral chemotherapy drug of the fluoropyrimidine family that is converted in the body into 5-fluorouracil, approved in the United States in 1998 and mainly used in colorectal and breast cancer.
Did you know?It is a 'three-step' prodrug: the final conversion into 5-fluorouracil is carried out by thymidine phosphorylase, an enzyme more abundant in tumour tissue than in healthy tissue.
The two levels compared
| Level 1 Mass balance | Level 2 Mass balance + qNMR | |
|---|---|---|
| Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR) | ✓ | ✓ |
| HPLC purity (min. 95%) | ✓ | ✓ |
| Content by mass balance (min. 90%; peptides: for information only)* | ✓ | ✓ |
| Content verified by qNMR (small molecules only) | · | ✓ |
| Suitable to qualify it as an in-house primary standard (ICH Q7) | · | ✓ |
* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.
What you receive
The analytical standard
Shipped under controlled temperature when the molecule requires it.
Certificate of analysis (CoA)
For every lot: identity, purity and assay, with the supporting spectra and chromatograms.
Safety data sheet (SDS)
Sent with every order.
Tracked shipment
Follow your shipment live, from our warehouse to your lab.
Pharmacopoeial standards available
The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.
- CapecitabineBP 1229
- Capecitabine CRSEP Y0001642
- Capecitabine impurity B CRSEP Y0001644
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Pharmacopoeial impurityCapecitabine IsomersCat. No. P-C024-009Frequently asked questions
Is mass balance always performed?
Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.
Can I ask for a different quantity?
Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.
Which level should I choose?
Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.
When will I get the quote?
Within 24 working hours, with price, availability and delivery time.
Need a molecule you cannot find?
Custom synthesis of impurities, metabolites and labelled compounds, with the same characterisation level.