Active ingredient · Chlorambucil family

Pharmaceutical analytical standard

Chlorambucil

Synonyms: 4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid, Ambochlorin, Chloroambucil, Leukeran, Chloraminophen, Chlorbutin, Chloraminophene, Amboclorin, Chlorobutine, Ecloril, Chlorbutine, Chlorobutin, Lympholysin, Linfolizin, Linfolysin, Elcoril, Phenylbutyric acid nitrogen mustard, Leukersan, Leukoran, Chlorbutinum, Clorambucilo, Elcorin, N,N-Di-2-chloroethyl-gamma-p-aminophenylbutyric acid, p-(N,N-Di-2-chloroethyl)aminophenyl butyric acid, Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-, gamma-(p-Bis(2-chloroethyl)aminophenyl)butyric acid, Para-(Di(2-chloroethyl)aminophenyl)butyric acid, gamma-(p-Di(2-chloroethyl)aminophenyl)butyric acid, p-N,N-Di-(beta-chloroethyl)aminophenyl butyric acid, Butyric acid, 4-(p-(bis(2-chloroethyl)amino)phenyl), Para-N,N-Di(beta-chloroethyl)aminophenyl butyric acid, N,N-Di-2-chloroethyl-gamma-para-aminophenyl butyric acid, Clorambucil, N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid, Chlocambucil, Chloorambucol, Kyselina 4-(N,N-bis-(2-chlorethyl)-p-aminofenyl)maselna, Clorambucile, p-(N,N-Di-2-chlorethylaminophenyl)butyric acid, Butanoic acid, 4-(bis(2-chloroethyl)amino) benzene

Cat. No.: P-C128-001
CAS: 305-03-3
Alternative CAS: N/A
Formula: C₁₄H₁₉Cl₂NO₂
Molecular weight: 304.21 g/mol
Category: Active ingredient (API)

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Characterisation level Level 1 Mass balanceFor small molecules, identity is confirmed by IR, MS, 1H-NMR and 13C-NMR, purity by HPLC (min. 95%) and assay by mass balance (min. 90%); for peptides and similar molecules, identity is confirmed by mass spectrometry (ESI-MS and MALDI-TOF) and IR, purity by HPLC (min. 95%) and assay by mass balance, reported for information only.* Level 2 Mass balance + qNMRFor small molecules, in addition to the Level 1 analyses, the assay is verified by qNMR, an orthogonal method independent of chromatography; for peptides and similar molecules, Level 2 is not available. Analytical documentation supporting qualification as an in-house primary standard under ICH Q7 (§11.17-11.18).

* Mass balance is performed on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it, for example oils and highly volatile substances, on which some of the required measurements cannot be made: in those cases the CoA states how the content was assigned.

Quantity

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We reply within 24 hours with a quote and availability. CoA and SDS with every lot.

An alkylating agent of the nitrogen mustard family, synthesised in 1953 by Everett, Roberts and Ross and approved in the United States in 1957: it is taken by mouth for chronic lymphocytic leukaemia and some lymphomas.

Did you know?It belongs to the 'aromatic' mustards, which react with DNA more slowly than the first nitrogen mustards: this makes them less toxic and allows them to be taken by mouth.

The two levels compared

	Level 1 Mass balance	Level 2 Mass balance + qNMR
Identity (IR, MS, 1H and 13C-NMR; peptides: ESI-MS, MALDI-TOF and IR)	✓	✓
HPLC purity (min. 95%)	✓	✓
Content by mass balance (min. 90%; peptides: for information only)*	✓	✓
Content verified by qNMR (small molecules only)	·	✓
Suitable to qualify it as an in-house primary standard (ICH Q7)	·	✓

What you receive

The analytical standard

Shipped under controlled temperature when the molecule requires it.

Certificate of analysis (CoA)

For every lot: identity, purity and assay, with the supporting spectra and chromatograms.

Safety data sheet (SDS)

Sent with every order.

Tracked shipment

Follow your shipment live, from our warehouse to your lab.

Pharmacopoeial standards available

The official European Pharmacopoeia standards for this molecule, supplied with EDQM documentation.

ChlorambucilBP 064
Chlorambucil CRSEP C1100000
Chlorambucil for system suitability CRSEP Y0001298
Chlorambucil with impurity G CRSEP Y0001299

More products in the Chlorambucil family

Pharmacopoeial impurityChlorambucil EP Impurity ACat. No. P-C128-002CAS 27171-89-7

Pharmacopoeial impurityChlorambucil EP Impurity BCat. No. P-C128-003CAS 116505-53-4

Pharmacopoeial impurityChlorambucil EP Impurity CCat. No. P-C128-004

Pharmacopoeial impurityChlorambucil EP Impurity DCat. No. P-C128-005CAS 94236-91-6

Pharmacopoeial impurityChlorambucil EP Impurity ECat. No. P-C128-006CAS 1988791-13-4

Pharmacopoeial impurityChlorambucil EP Impurity FCat. No. P-C128-007

Pharmacopoeial impurityChlorambucil EP Impurity GCat. No. P-C128-008CAS 178481-89-5

Isotopically labelledChlorambucil-d8Cat. No. P-C128-009CAS 2748247-26-7

See all 15 products in the family

Frequently asked questions

Is mass balance always performed?

Yes, on every molecule. The only exceptions are cases where the chemistry of the molecule prevents it: for example oils and highly volatile substances, on which some measurements (such as thermogravimetry) cannot be made. In those cases the CoA states which method was used to assign the content.

Can I ask for a different quantity?

Yes. The quantities are only suggestions: choose "Other" and enter the milligrams or grams you need.

Which level should I choose?

Level 1 is enough for most routine testing. Level 2 adds an independent qNMR content value and is meant for labs that need to qualify an in-house primary standard. For peptides and similar molecules, Level 2 is not available.

When will I get the quote?

Within 24 working hours, with price, availability and delivery time.

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